口腔生化学分野 朝日大学歯学部 口腔構造機能発育学講座


 【 最近の業績 】 論 文    競争的資金研究課題はこちら
 (原著) 
  2020年     2019年     2018年     2017年     2016年   
  2015年     2014年     2012年     2011年 
  2010年     2009年     2008年    

 2020年

◆Nomura S, Morimoto Y, Tsujimoto H, Arake M, Harada M, Saitoh D, Hara I, Ozeki E, Satoh A, Takayama E, Hase K, Kishi Y, Ueno H. Highly reliable, targeted photothermal cancer therapy combined with thermal dosimetry using a near-infrared absorbent. Sci Rep, In press.


◆Mizuno H, Takayama E, Satoh A, Into T, ADACHI Adachi M, Ekuni D, Yashiro K, Misuno-Kamiya M, Nagayama M, Saku S, Tomofuji T, Doi Y, Murakami Y, Kondoh N, Morita M. Horseradish peroxidase interacts with the cell wall peptidoglycans on oral bacteria. Exp Ther Med, In press.


◆Dai H, Lan P, Zhao D, Abou-Daya K, Liu W, Chen W, Friday AJ, Williams AL, Sun T, Chen J, Chen W, Mortin-Toth S, Danska JS, Wiebe C, Nickerson P, Li T, Mathews LR, Turnquist HR, Nicotra ML, Gingras S, Takayama E, Kubagawa H, Shlomchik MJ, Oberbarnscheidt MH, Li XC, Lakkis FG. PIRs mediate innate myeloid cell memory to nonself MHC molecules. Science, In press. May 2020. doi: 10.1126/science.aax4040.


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 2019年
◆Kondoh N, Mizuno-Kamiya M, Umemura N, Takayama E, Kawaki H, Mitsudo K, Muramatsu Y, Sumitomo S. Immunomodulatory aspects in the progression and treatment of oral malignancy. Jpn Dent Sci Rev, 55(1):113-120, Nov 2019. doi: 10.1016/j.jdsr.2019.09.001.

◆Kyohei Ueno, Hideyuki Negishi, Takuya Okuno, Hiromasa Tawarayama, Shinji Ishikawa, Manabu Miyamoto, Shigeyuki Uemiya, Yasunori Oumi. Effects of seed crystal type on the growth and microstructures of silicalite-1 membranes on tubular silica supports via gel-free steam-assisted conversion. Microporous and Mesoporous Materials 289, doi:10.1016/j.micromeso.2019.109645, Nov 2019.


◆Reina Inoue, Kyohei Ueno, Saki Yamada, Hideyuki Negishi, Manabu Miyamoto, Shigeyuki Uemiya, Yasunori Oumi. Preparation of novel hydrophilic microporous material PML-1 membrane by topotactic transformation of layered silicate SSA-1 and applicability to the dehydration of aqueous acetic acid. Microporous and Mesoporous Materials 285, doi:10.1016/j.micromeso.2019.05.022, Sep 2019.


◆Ueno K, Yamada S, Watanabe T, Negishi H, Okuno T, Tawarayama H, Ishikawa S, Miyamoto M, Uemiya S, Oumi Y. Hydrophobic *BEA-Type Zeolite Membranes on Tubular Silica Supports for Alcohol/Water Separation by Pervaporation. Membranes 9(4) 46, doi:10.3390/membranes9070086, Jul 2019.


◆Arai M, Imamura O, Kondoh N, Dateki M, Takishima K. Neuronal Ca(2+) –dependent activator protein 1 (NCDAP1) induces neuronal cell death by activating p53 pathway following traumatic brain injury. J Neurochem. 2019 Jun 25. doi: 10.1111/jnc.14803.


◆Ueno Kyohei, Negishi Hideyuki, Okuno Takuya, Tawarayama Hiromasa, Ishikawa Shinji, Miyamoto Manabu, Uemiya Shigeyuki, Oumi Yasunori. Effects of Silica-Particle Coating on a Silica Support for the Fabrication of High-Performance Silicalite-1 Membranes by Gel-Free Steam-Assisted Conversion. Membranes 9(4), doi:10.3390/membranes9040046, Apr 2019.


◆Morimoto-Ito H, Mizuno-Kamiya M, Umemura N, Inagaki Y, Takayama E, Kawaki H, Muramatsu Y, Sumitomo S, Kondoh N. Immunosuppressive effect of mesenchymal stromal cells is enhanced by IL-1α from oral squamous cell carcinoma cells. Open Dent J. 2019, 13(1): 221-227, doi: 10.2174/1874210601913010221.

◆Omiya Y, Hagiwara N, Shinohara S, Nakamura M, Higuchi M, Mitsuyoshi S, Takayama E, Shinichi Tokuno S-I. The influence of the voice acquisition method to the mental health state estimation based on vocal analysis. IFMBE Proceedings IUPESM World Congress on Medical Physics and Biomedical Engineering, 68(1):327-330, 2019.

近江靖則, 上野恭平. シリカ支持体を用いたシリカライト膜の合成(特集 分離膜の材料設計とスケールアップ実現に向けた最近のアプローチ)分離技術 49(4), 2019.

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 2018年

◆Masuda J, Shigehiro T, Matsumoto T, Satoh A, Mizutani A, Umemura C, Saito S, Kijihira M, Takayama E, Seno A, Murakami H, Seno M. Cytokine expression and macrophage localization in xenograft and allograft tumor models stimulated with lipopolysaccharide. Int J Mol Sci, Apr 23; 19(4). pii: E1261. doi: 10.3390/ijms19041261, PMID: 29690614, 2018.


◆Masuda J, Takayama E, Ichinohe T, Strober W, Mizuno-Kamiya M, Ikawa T, Kitani A, Kawaki H, Fuss IJ, Kawamoto H, Seno A, Vaidyanath A, Umemura N, Mizutani A, Kasai T, Honjo Y, Satoh A, Murakami H, Katsura Y, Kondoh N, Seno M. Immunosuppression effect by adipose tissue-derived mesenchymal stem cells isolated from β2-microglobulin deficient mice. Exp Ther Med, 16(5):4277-4282, Nov 2018. doi:10.3892/etm.2018.6689. Epub 2018 Sep 4. PMID: 30344701


◆Sumi S, Umemura N, Adachi M, Ohta T, Naganawa K, Kawaki H, Takayama E, Kondoh N, Sumitomo S. The luminance ratio of autofluorescence in a xenograft mouse model is stable through tumor growth stages. Clin Exp Dent Res, Aug 15; 4(5): 174-181. doi: 10.1002/cre2.126. eCollection 2018 Oct, PMID: 30386639, 2018.


◆Kondoh N, Mizuno-Kamiya M, Takayama E, Kawaki H, Umemura N, Yamazaki Y, Mitsudo K, Tohnai I. Perspectives of Immune suppression in the tumor microenvironment promoting oral malignancy. Open Dent J, Jun 20; 12: 455-465. doi: 10.2174/1874210601812010455. eCollection 2018. Review. PMID: 29988281, 2018.


◆Adachi M, Mizuno-Kamiya M, Takayama E, Kawaki H, Umemura N, Inagaki T, Sumi S, Motohashi M, Muramatsu Y, Sumitomo S, Shikimori M, Yamazaki Y, Kondoh N. Gene expression analyses associated with malignant phenotypes of metastatic subclones derived from a mouse oral squamous cell carcinoma cell line, Sq-1979. Oncol Lett, Mar;15(3): 3350-3356. doi: 10.3892/ol.2017.7648. Epub 2017 Dec 19. PMID: 29435078, 2018.


◆Inagaki T, Mizuno-Kamiya M, Takayama E, Kawaki H, Chihara E, Muramatsu Y, Sumitomo S, Kondoh N. Suppressive effect of mesenchymal stromal cells on interferon-γ-producing capability of spleen cells was specifically enhanced via humoral mediator(s) from mouse oral squamous cell carcinoma Sq-1979 cells in vitro. Cancer Transl Med, 4(1): 9–16, doi: 10.4103/ctm.ctm_34_17, 2018.


◆Gul HI, Tugrak M, Gul M, Sakagami H, Umemura N, Anil B. Synthesis and Cyototoxicities of New Azafluorenones with Apoptotic Mechanism of Action and Cell Cycle Analysis. Anti-cancer agents in medicinal chemistry, doi: 10.2174/1871520618666180525085445, May 2018.


◆Nanbu T, Umemura N, Ohkoshi E, Nanbu K, Sakagami H, Shimada J. Combined SN-38 and gefitinib treatment promotes CD44 degradation in head and neck squamous cell carcinoma cells. Oncology reports 39(1), doi: 10.3892/or.2017.6105, Jan 2018.


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 2017年

◆Masuda J, Takayama E, Strober W, Satoh A, Morimoto Y, Honjo Y, Ichinohe T, Tokuno S, Ishizuka T, Nakata T, Mizutani A, Umemura N, Kitani A, Fuss IJ, Shigehiro T, Kawaki H, Mizuno-Kamiya M, Kondoh N, Seno M. Tumor growth limited to a single site vs tumor growth in multiple sites exhibit differential effects on systemic immunities. Oncol Rep,38(1):449-455, Jul 2017. doi: 10.3892/or.2017.5646. Epub 2017 May 17. PMID: 28535011


◆Sumi S, Umemura N, Takayama E, Ohkoshi E, Adachi M, Mizuno-Kamiya M, Inagaki T, Kawaki H, Sumitomo S, Kondoh N. Metastasized murine oral squamous cell carcinoma cells induce intratumoral polymorphonuclear myeloid derived suppressor cells. Oncol Rep. 37(5):2897-2904, May 2017. doi: 10.3892/or.2017.5575. Epub 2017 Apr 11. PMID: 28405677


◆Azuma Y, Mizuno-Kamiya M, Takayama E, Kawaki H, Inagaki T, Chihara E, Muramatsu Y Kondoh N. The producing capabilities of interferon (IFN)-g and interleukin (IL)-10 of spleen cells in primary and metastasized oral squamous cell carcinoma cells-implanted mice. Cancer Transl Med, 3(6): 194-199, 2017.


◆Kawata K, Kubota S, Eguchi T, Aoyama E, Moritani NH, Oka M, Kawaki H, Takigawa M. A Tumor Suppressor Gene Product, Platelet-Derived Growth Factor Receptor-Like Protein Controls Chondrocyte Proliferation and Differentiation. J Cell Biochem. 2017 Nov;118(11):4033-4044. doi: 10.1002/jcb.26059. Epub 2017 May 23. PMID: 2840730


◆Kubota S, Kawaki H, Takigawa M. Protocols for Screening Peptide Motifs Binding to CCN Family Proteins. Methods Mol Biol. 2017;1489:155-167. PMID: 27734375


◆Kawaki H, Kubota S, Takigawa M. Analysis of Signaling Pathways Activated by CCN Proteins. Methods Mol Biol. 2017;1489:139-143. PMID: 27734373


◆Kubota S, Kawaki H, Takigawa M. ELISA of CCN Family Proteins in Body Fluids Including Serum and Plasma. Methods Mol Biol. 2017;1489:127-138.


◆Kawaki H, Kubota S, Takigawa M. Immunohistochemical Analysis of CCN Proteins in Calcified Tissues. Methods Mol Biol. 2017;1489:53-62. PMID: 27734365


◆Kawaki H, Kubota S, Takigawa M. Western Blotting Analysis of CCN Proteins in Calcified Tissues. Methods Mol Biol. 2017;1489:43-51. PMID: 27734364


◆Kawaki H, Kubota S, Takigawa M. Analysis of Expression of CCN Family Genes in Skeletal Tissue-Derived Cells. Methods Mol Biol. 2017;1489:33-41. PMID: 27734363


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 2016年

◆Adachi N, Takayama E, Adachi M, Mizuno-Kamiya M, Kawaki H, Takeuchi H, Kubo S, Ishigami H, Kurachi M, Kondoh N. Promotion of Nickel (Ni) Allergy by Anamnestic Sensitization with a Bacterial Component, Lipopolysaccharide (LPS), in Mice. Open Dent J, 10:531-537, 30 Sep 2016. eCollection 2016. PMID: 27843506.


◆Masuda J, Kawamoto H, Strober W, Takayama E, Mizutani A, Murakami H, Ikawa T, Kitani A, Maeno N, Shigehiro T, Satoh A, Seno A, Arun V, Kasai T, Fuss IJ, Katsura Y, Seno M. Transient Tcf3 Gene Repression by TALE-Transcription Factor Targeting. Appl Biochem Biotechnol, 180(8):1559-1573 Dec 2016. Epub 2016 Jul 12. PMID: 27406037.


◆Murase Y, Hattori T, Aoyama E, Nishida T, Maeda-Uematsu A, Kawaki H, Lyons KM, Sasaki A, Takigawa M, Kubota S. Role of CCN2 in Amino Acid Metabolism of Chondrocytes.J Cell Biochem. 2016 Apr;117(4):927-37. doi: 10.1002/jcb.25377. Epub 2015 Sep 22.


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 2015年

◆Naganawa K, Takayama E, Adachi M, Mitsudo K, Iida M, Kamiya-Mizuno M, Kawaki H, Ichinose M, Motohashi M, Muramatsu Y, Tohnai I, Sumitomo S, Shikimori M, Kondoh N. Producing Capabilities of Interferon-gamma and Interleukin-10 in Peripheral Blood from Oral Squamous Cell Carcinoma Patients. Open Dent J, 9: 120-124, 31 Mar 2015. doi: 10.2174/1874210601509010120. eCollection 2015. PMID: 25893021.


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 2014年

◆Iida M, Takayama E, Naganawa K, Mitsudo K, Adachi M*, Baba J, Fujimoto-Muto M, Motohashi M, Mizuno-Kamiya M, Kawaki H, Kioi M, Ichinose M, Sumitomo S, Muramatsu Y, Shikimori M, Tohnai I, Kondoh N. Increase of Peripheral Blood CD57+ T-Cells in Patients with Oral Squamous Cell Carcinoma. Anticancer Res, 34(10):5729-5734, Oct 2014. PMID: 25275081.


◆Kubagawa H, Oka S, Kubagawa Y, Torii I, Takayama E, Kang DW, Jones D, Nishida N, Miyawaki T, Bertoli LF, Sanders SK, Honjo K. The long elusive IgM Fc receptor, FcμR. J Clin Immunol, 34 Suppl 1:S35-45, Jul 2014. doi: 10.1007/s10875-014-0022-7. Epub 2014 May 3. Review. PMID: 24793544.


◆Nagaya R, Mizuno-Kamiya M, Takayama E, Kawaki H, Onoe I, Tanabe T, Nagahara K, Kondoh N. Mechanisms of the immunosuppressive effects of mouse adipose tissue-derived mesenchymal stromal cells on mouse alloreactively stimulated spleen cells. Exp Ther Med, 7(1):17-22, Jan 2014. Epub 2013 Nov 6. PMID: 24348757.


◆Maeda-Uematsu A, Kubota S, Kawaki H, Kawata K, Miyake Y, Hattori T, Nishida T, Moritani N, Lyons KM, Iida S, Takigawa M. CCN2 as a novel molecule supporting energy metabolism of chondrocytes. J Cell Biochem. 2014 May;115(5):854-65. doi: 10.1002/jcb.24728. PMID: 24288211.


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 2012年

◆Ono T, Yamaguchi Y, Oguma T, Takayama E, Takashima Y, Tadakuma T, Miyahira Y. Actively induced antigen-specific CD8+ T cells by epitope-bearing parasite pre-infection but not prime/boost virus vector vaccination could ameliorate the course of Plasmodium yoelii blood-stage infection. Vaccine, 30(44):6270-6278, 28 Sep 2012. doi: 10.1016/j.vaccine.2012.08.009. Epub 2012 Aug 16. PMID: 22902783.


◆Into T, Inomata M, Takayama E, Takigawa T. Autophagy in regulation of Toll-like receptor signaling. Cell Signal, 24(6):1150-1162, Jun 2012. doi: 10.1016/j.cellsig.2012.01.020. Epub 2012 Feb 4. Review. PMID: 22333395.


◆Kondoh N, Takayama E, Kamiya M, Kawaki H, Motohashi M, Muramatsu Y, Shikimori M, Mitsudo K, Tohnai I. Comprehensive study of oral squamous cell carcinoma patients using blood samples and gene expression profiles. J Cancer Sci Ther S18: 001, 2012. doi:10.4172/1948-5956.S18-001.


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 2011年

◆Ohgawara T, Kubota S, Kawaki H, Kurio N, AbdEl Kader T, Hoshijima M, Janune D, Shimo T, Perbal B, Sasaki A, Takigawa M. Association of the metastatic phenotype with CCN family members among breast and oral cancercells. J Cell Commun Signal., 5: 291-299, 2011.

◆Janune D, Kubota S, Nishida T, Kawaki H, Perbal B, Iida S, Takigawa M. Differential roles of CCN family proteins during osteoblast differentiation: Involvement of Smad and MAPK signaling pathways. Bone., 49: 975-989, 2011.

◆Janune D, Kubota S, Nishida T, Kawaki H, Perbal B, Iida S, Takigawa M. Novel effects of CCN3 that may direct the differentiation of chondrocytes. FEBS Lett., 585: 033-3040, 2011.

◆Shiraki T, Takayama E, Magari H, Nakata T, Maekita T, Enomoto S, Mori Y, Shingaki N, Moribata K, Deguchi H, Ueda K, Inoue I, Mizuno-Kamiya M, Yashiro K, Iguchi M, Tamai H, Kameyama Y, Kato J, Kondoh N, Ichinose M. Altered cytokine levels and increased CD4+ CD57+ T cells in the peripheral blood of hepatitis C virus-related hepatocellular carcinoma patients. Oncol Rep, 26(1):201-208, Jul 2011. doi: 10.3892/or.2011.1258. Epub 2011 Apr 12. PMID: 21491089.

◆Nakata T, Takayama E, Magari H, Kato J, Kondo N, Ichinose M. Simultaneous detection of T lymphocyte-related antigen (CD4/CD8, CD57, TCR beta) with nuclei by fluorescent-based immunohistochemistry in paraffin-embedded human lymph node, liver cancer and stomach cancer. Acta Cytol, 55(4):357-363, 2011. doi: 10.1159/000329487. Epub 2011 Jul 22. PMID: 21791906.
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 2010年
◆Takayama E, Ono T, Carnero E, Umemoto S, Yamaguchi Y, Kanayama A, Oguma T, Takashima Y, Tadakuma T, García-Sastre A, Miyahira Y. Quantitative and qualitative features of heterologous virus-vector-induced antigen-specific CD8(+) T cells against Trypanosoma cruzi infection. Int J Parasitol, 40(13):1549-1561, Nov 2010. doi: 10.1016/j.ijpara.2010.05.011. Epub 2010 Jul 8. PMID: 20620143.
◆Kondoh N, Kameyama Y, Yashiro K, Takayama E, Kamiya M.   Gene expression signatures for the Diagnosis of Oral Malignancy.   J Gifu Dent Soc, 2010 Feb, 36(3), 121-30.
◆Fujihara C, Yamada S, Ozaki N, Takeshita N, Kawaki H, Takano-Yamamoto T, Murakami S. Role of mechanical stress-induced glutamate signaling-associated molecules in cytodifferentiation of periodontal ligament cells. J Biol Chem. 2010 . 285:28286-28297
◆Kawaki H, Kubota S, Aoyama E, Fujita N, Hanagata H, Miyauchi A, Nakai K, Takigawa M. Design and utility of CCN2 anchor peptide aptamers. Biochimie. 2010. 92:1010-1015.
◆Imura H, Yamada T, Mishima K, Fujiwara K, Kawaki H, Hirata A, Sogawa N, Ueno T, Sugahara T. Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin suggests abnormal palate development after palatal fusion. Congenit Anom (Kyoto). 2010.
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 2009年
◆Kubagawa H, Oka S, Kubagawa Y, Torii I, Takayama E, Kang DW, Gartland GL, Bertoli LF, Mori H, Takatsu H, Kitamura T, Ohno H, Wang JY. Identity of the elusive IgM Fc receptor (FcmR) in humans. J Exp Med, 206(12):2779-2793, 23 Nov 2009. doi: 10.1084/jem.20091107. Epub 2009 Oct 26. PMID: 19858324.
◆Arai M, Kondoh N, Imazeki N, Hada A, Hatsuse K, Matsubara O, and Yamamoto M. The knockdown of endogenous RFC4 decreases the growth and enhances the chemosensitivity of hepatocellular carcinoma cells. Liver Int., 2009.
◆Sumiyoshi K, Kubota S, Furuta RA, Yasui K, Aoyama E, Kawaki H, Kawata K,Ohgawara T, Yamashiro T, Takigawa M. Thrombopoietic-mesenchymal interaction that may facilitate both endochondral ossification and platelet maturation via CCN2. J Cell Commun Signal. 2009. 4:5-14.
◆Ohgawara T, Kubota S, Kawaki H, Kondo S, Eguchi T, Kurio N, Aoyama E, Sasaki A, Takigawa M. Regulation of chondrocytic phenotype by micro RNA 18a: involvement of Ccn2/Ctgf as a major target gene. FEBS Lett. 2009. 583:1006-1010.
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 2008年
◆Ueda S, Kondoh N, Tsuda H, Yamamoto S, Asakawa H, Fukatsu K, Kobayashi T, Yamamoto J, Tamura K, Ishida J, Abe Y, Yamamoto M and Mochizuki H. Expression of centromere protein F (CENP-F) associated with higher FDG uptake on PET/CT, detected by c DNA microarray, predicts high-risk patients with primary breast cancer. BMC Cancer 2008, 8:384 (22 Dec 2008).
◆Shiokawa K, Aso M, Kondo T, Uchiyama H, Kuroyanagi S, Takai J, Takahashi S, Kajitani M, Kaito C, Sekimizu K, Takayama E, Igarashi K, Hara H. Gene Expression in Pre-MBT Embryos and Activation of Maternally-Inherited Program of Apoptosis to be Executed at around MBT as a Fail-Safe Mechanism in Xenopus Early Embryogenesis. Gene Regul Syst Bio. 2008 May 29;2:213-231
◆Kondoh N, Ishikawa T,Ohkura S,Arai M, Hada A, Yamazaki Y, Kitagawa Y, Shindoh M, Takahashi M, Ando T, Sato Y, Izumo T, Hitomi K and Yamamoto M. Gene expression signatures that classify the mode of invasion of primary oral squamous cell carcinomas. Mol Carcinog,47: 744-756,2008.
◆Ohkura-Hada S, Kondoh N, Hada A, Arai M, Yamazaki Y, Shindoh M, Kitagawa Y, Takahashi M, Ando T, Sato Y and Yamamoto M. Carbonil reductase (CBR3) mediates 9-cis-retinoic acid-induced cytostatis and is a potent prognostic marker for oral malignancy. The Open Dentistry Journal 2; 78-88, 2008.

◆Ueda S, Tsuda H, Asakawa H, Shigekawa T, Fukatsu K, Kondoh N, Yamamoto M, Hama Y, Tamura K, Ishida J, Abe Y and Mochizuki H. Clinicopathological and prognostic relevance of uptake level using 18F-fluorodexyglucose positron emission tomography / computed tomography fusion imaging (18F-FDG PET/CT) in primary breast cancer. Jpn J Clin Oncol, 38(4): 250-258, 2008.
◆Yamanaka, M., Kimura, F., Kagata, Y., Kondoh, N., Asano, T., Yamamoto, M. and Hayakawa, M. BIGH3 is overexpressed in clear cell renal cell carcinoma. Oncol. Rep., 19(4):865-74. 2008.
◆Yashiro, K., Kitamura, K., Mizuno-Kamiya, M., Kameyama, Y. and Fujita, A.  Activities of cytosolic glutathione peroxidase and phospholipid hydroperoxide glutathione peroxidase in rat salivary glands.  J. Gifu Dent. Soc. 35, 1-6, 2008.

◆Kameyama, Y., Mizuno-Kamiya, M., Yashiro, K., Fujita, A. Substrate specificity of microsomal 1-acyl-sn-glycero-3-phosphocholine acyltransferase in rat salivary parotid glands for polyunsaturated long-chain acyl-CoAs. J. Gifu Dent. Soc. 34:105-109, 2008.

◆Kameyama, Y., Kitamura, K., Yashiro, K., Mizuno-Kamiya, M. Fujita, A. The significance of cytoskeleton in exocytosis : control of apical plasma membrane-evoked amylase release from secretory granules isolated from the rat parotid gland. J. Gifu Dent. Soc. 34:99-104, 2008.
◆Kameyama, Y., Kitamura, K., Yashiro, K., Mizuno-Kamiya, M., Fujita, A. Physical properties of subcellular membrane fractions isolated from rat salivary glands. J. Gifu Dent. Soc. 34:93-98, 2008.
◆Kameyama, Y, Fujita, A. The increase of reacylation enzyme activities which synthesizephosphatidylcholine and phosphatidylinositol in microsomesfrom rat submandibular gland during growth. MEDICINE AND BIOLOGY 152:14-19, 2008.
◆Kameyama, Y, Fujita, A. The regulatory effect of microfilaments in exocytosis: direct fusion assay by fluorescence dequenching in an in vitro interaction system using purified secretory granules and apical plasma membranes from the rat parotid gland. MEDICINE AND BIOLOGY 152:9-13, 2008.
◆Sugasawa H, Ichikura T, Kinoshita M, Ono S, Majima T, Tsujimoto H,Chochi K, Hiroi S, Takayama E, Saitoh D, Seki S, Mochizuki H.Gastric cancer cells exploit CD4+ cell-drived CCL5 for their growth and prevention of CD8+ cell-involved tumor elimination.Int J Cancer. 2008 Jun 1;122(11):2535-41.

◆Mukudai Y, Kubota S, Kawaki H, Kondo S, Eguchi T, Sumiyoshi K, Ohgawara T, Shimo T, Takigawa M. Post-transcriptional regulation of chicken ccn2 gene expression by nucleophosmin/B23 during chondrocyte differentiation. Mol Cell Biol. 2008. 28:6134-6147..


◆Kawaki H, Kubota S, Suzuki A, Lazar N, Yamada T, Matsumura T, Ohgawara T, Maeda T, Perbal B, Lyons KM, Takigawa M. Cooperative Regulation of Chondrocyte Differentiation by CCN2 and CCN3 Revealed by a Comprehensive Analysis of the CCN Family Proteins in Cartilage. J Bone Miner Res. 2008. 23:1751-1764..


◆Vincourt JB. Vignaud JM. Lionneton F. Sirveaux F. Kawaki H. Marchal S. Lomazzi S. Plenat F. Guillemin F. Netter P. Takigawa M. Mainard D. Magdalou J. Matrilin-3 increases not only upon osteoarthritis but also in cartilage-forming tumours and down-regulates SOX9 via EGF domain 1-dependent signaling.Arthritis Rheum. 2008. 58:2798-2808.


◆Kikuchi T. Kubota S. Asaumi K. Kawaki H. Nishida T. Kawata K. Tabata Y. Takigawa M. Promotion of bone regeneration by CCN2 incorporated into gelatin hydrogel. Tissue Eng. Part A. 2008. 14:1089-1098..


◆Ono M, Kubota S, Fujisawa T, Sonoyama W, Kawaki H, Akiyama K, Shimono K, Oshima M, Nishida T, Yoshida Y, Suzuki K, Takigawa M, Kuboki T. Promotion of hydroxyapatite-associated, stem cell-based bone regeneration by CCN2. Cell Transplant. 2008. 17:231-240.


◆Kawaki H, Kubota S, Suzuki A, Yamada T, Matsumura T, Mandai T, Yao M, Maeda T, Lyons KM, Takigawa M. Functional requirement of CCN2 for intramembranous bone formation in embryonic mice. Biochem Biophys Res Commun. 2008. 366:450-456..


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 Department of Oral Biochemistry, Asahi University School of Dentistry